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Constipated patients with comorbid depression exhibit more severe bloating, abdominal pain, and sense of incomplete evacuation, with lower defecation frequency and harder stool consistency (Koloski et al., 2002)

Meta-analyses show mean differences in HbA1c reductions versus placebo of 1.4% to 0.5% [20, 22, 24,25,26,27]

Launched in 2004 by Denver Health, a comprehensive care safety net organization, it now covers about 89,000 enrollees in Denver, Adams, Arapahoe and Jefferson counties