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Description

Clinicians use the term informally to describe vaginal or vulvar changes noticed while taking a GLP-1 agonist

D.QuerciF.et al (2010b)

The questions that Phase 3 will need to answer and that regulators will scrutinize closely include cardiovascular outcomes over extended periods, liver function changes beyond the 48-week window, potential interactions with other metabolic agents, and safety in populations not well-represented in Phase 2

GLP-1 receptors are found in the brain, and GLP-1 signaling may influence appetite, glucose regulation, inflammation, vascular function, and possibly neuronal stress pathways