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Due to a concern for inducing malignancy [a total of 10 cases in the active treatment arm of melanoma, ovarian carcinoma, pancreatic carcinoma, and myelodysplastic syndrome (63)] cladribine was rejected by FDA in 2010

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They were maintained under a 12 h light-dark cycle (lights on from 8:00 AM to 6:00 PM) at a temperature conducive to mouse survival (2325 C) and 50% humidity, with ad libitum access to water and food