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Why a Bubble or Lump Can Appear Under the Skin After Injection A soft bump or bubble under the skin can form when the needle is not fully inserted and medication pools in the very superficial tissue instead of the proper subcutaneous layer

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More specifically, GLP-1R expression has been identified in several hypothalamic and basal forebrain regions, including the paraventricular nucleus, supraoptic nucleus, infundibular nucleus/arcuate nucleus, lateral hypothalamic area, and nuclei of the basal forebrain, where they exhibit relatively well-defined regional expression patterns (43, 44)