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Combining AKR1C3 inhibitors with ATP-binding cassette transporter (ABCB1) inhibitors may overcome PTX resistance in breast cancer (Matsunaga et al., 2023)

111 Similar to SRLs, GHRH antagonists inhibit endocrine secretion of GH from the anterior pituitary to varying extents

In A549/ADR (DOX-resistant human lung adenocarcinoma cell) tumor-bearing nude mice, administration of DD-H/P NCs completely inhibited tumor growth, prolonged survival with an 80% survival rate, and significantly increased DOX accumulation in tumor sites compared with the free drug group, with no obvious toxicity in major organs [115]

The sensitivity of R 4 parameters ( k p4 ) with respect to model OCR output is in good accordance with the AIC/BIC analysis, confirming the need for the R 4 reaction, which is present in both the triad and the comproportionation models, but not in the reduced model