6 weeks on semaglutide Does work right away? What happens after your first dose 140 lbs Semaglutide 6-Week Belly

the time from first dose to rescue medication use was not significantly different between any of the oral semaglutide doses and sitagliptin 100 mg (ESM Table 3)

[4] [5] Semaglutide works by mimicking the incretin hormone GLP-1, which stimulates insulin secretion in a glucose-dependent manner, suppresses glucagon release, slows gastric emptying, and reduces appetite through central nervous system pathways

Frontiers in Pharmacology , 14 , 11326501132659

Dehydration represents an important factor, as GLP-1 medications can cause nausea, vomiting, and diarrhea, particularly during dose escalation, leading to volume depletion