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Multiple melanoma risk factors such as familial history, sunseeking behaviour and other genetic factors, including MC1R variants, may increase the risk associated with melanotan II

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Obesity drives more than $260 billion in annual U.S

Published trials are sparse, but a 2023 observational study reported modest additional weight loss (35 lbs over 12 weeks) with combination therapy versus single-agent, though nausea and dizziness occurred in 34% of patients

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