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In clinical trials for non-GI wounds, including diabetic ulcers and Mohs surgical wounds, GHK-Cu demonstrated significantly improved re-epithelialization

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Extensive experimental and computational studies have shown that the binding of GSH to GSTs decreases the p K a of the GSH thiol group from around 9 to about 6 in the active site through hydrogen bonding and salt bridges and through the positive electrostatic potential of the G-site 41,42

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