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Normally, FOXO4 binds to p53, preventing senescent cells from undergoing apoptosis

The signal stability was assured by normalizing the controls between runs to the sum of all signals between separate runs using Metaboanalyst (Xia and Wishart 2011)

This difference was likely attributable to the insufficient inhibition of excessive GJ proteins in hepsin / mice in response to the lower 2APB dose of 1 mg/kg, lending further support to the hypothesis that hepsin may help reduce APAP toxicity by regulating the expression of hepatic GJ proteins

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