Common side effects of sitagliptin include: Diarrhea Headache Nausea Sore throat Stuffy or runny nose Swelling of hands or legs Upper respiratory infection Serious sitagliptin side effects include: Allergic reactions (hives, difficulty breathing or swelling of the lips, face, tongue or throat) Heart failure (rapid increase in weight, shortness of breath or swelling of the feet) Hypoglycemia (low blood sugar) Necrotizing pancreatitis (a complication of acute pancreatitis that causes tissue death) Acute pancreatitis (inflammation in the pancreas, causing abdominal pain) Severe joint pain Severe skin reaction (rash, blistering or peeling, burning eyes or facial swelling) Increased blood glucose, pancreatitis, pancreatic cancer and gastrointestinal disorders (vomiting, diarrhea and nausea) were the most commonly reported side effects of Januvia and Janumet to the FDAs Adverse Event Reporting System (FAERS)

Shahabadi N, Zendehcheshm S, Khademi F (2021) Selenium nanoparticles: Synthesis, in-vitro cytotoxicity, antioxidant activity and interaction studies with ct-DNA and HSA, HHb and Cyt c serum proteins
But when the right cellular receptors sense toxins, they signal your genes to flip the switch and start the process to make GSH
doi: 10.1038/nbt841 137 CouriCEOliveiraMCStracieriABMoraesDAPieroniFBarrosGMet al