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A unique heirloom variety, Parish Leaf (Nostrano del Brenta), a Havana-seed tobacco, has been cultivated in Veneto since 1550 (Toscano Brenta)

In urban areas, where they are mindlessly tossed aside on sidewalks and streets, butts are an especially pervasive problem

Volunteer participants were randomly assigned to a group that received either research cigarettes containing the usual amount of nicotine (11.6 mg nicotine/cigarette) or a progressively reduced amount of nicotine for an additional 18-week period (the final amount was 0.2 mg nicotine/cigarette)

These devices heat a liquid known as vape juice or e-liquid, which contains nicotine or THC, along with propylene glycol, vegetable glycerin, and flavorings