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The specific vulnerability of the gastrointestinal system to TD, in the absence of more common signs of wet and dry beriberi, may arise from direct exposure of this system to the gut microbiome and oral drugs, along with the continuous need to redistribute thiamine to other tissues

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Indeed Shibao and coauthors demonstrated that after ganglionic blockade with trimethaphan, hypertensive obese patients exhibited a greater BP fall than the normotensive ones (Shibao et al., 2007)