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This action reduces the activation of the apoptosis pathway induced by IR, subsequently downregulating the expression levels of cytochrome c oxidase subunit 4 (Cox-4), Bax, and cleaved caspase-3, while also decreasing the secretion of TNF-, IL-1, and IL-6 (Zhang et al., 2021)

Increased plasma estrone and estradiol levels at atrazine doses of 50200 mg/kg/day were associated with elevated aromatase expression and impaired fluid absorption in the efferent ductules of the testes

First, animal model development should prioritize the physiological and behavioral relevance to human tinnitus, incorporating refined induction protocols, cross-species validation, and translational biomarkers measurable in both preclinical and clinical settings

Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain