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The oldest citation is from 2007, and 93% of the references were published in the last 6 years (2018 to 2024)
17 Therefore, when designing a dual agonist, either His or Tyr can be chosen for position 1 by weighing the required GLP-1 and GIP activity, and Phe is also worth considering
doi: 10.1210/jc.2008-1357 Summary Keywords growth hormone, insulin-like growth factor-I, intra-portal insulin, acromegaly, adult growth hormone deficiency, hepatic growth hormone sensitivity Citation Yuen KCJ, Hjortebjerg R, Ganeshalingam AA, Clemmons DR and Frystyk J (2024) Growth hormone/insulin-like growth factor I axis in health and disease states: an update on the role of intra-portal insulin
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