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The increased level of polyamines causes DNA fragmentation, chromatin condensation, and the generation of ROS, leading to apoptotic death [113, 114]

13b, Supplementary Table 9), indicating that the interactions between the C-terminal tyrosine and RAMP3 can compensate, in this peptide context, the reduced CTR ECD affinity derived from the P37Y substitution

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Histolgicamente, el SLH se caracteriza por acumulacin de melanina en los queratinocitos basales, sin aumento de la poblacin de melanocitos, y por un abundante nmero de melanfagos en la dermis superficial o corion9,10