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Acknowledgments The authors would like to thank the National Council for Scientific and Technological Development (CNPq) (Grant: 448905/2014-0 to A.A.S.R.)

Some equine injections may have mild side effects, such as temporary swelling or discomfort at the injection site

Key points Diabetic sensorimotor peripheral neuropathy (DSPN) is a common complication of diabetes mellitus that is associated with increased mortality, neuropathic pain, foot ulceration and lower-limb amputation