The standard dosing schedule begins with a low starting dose, followed by gradual escalation over 4-6 weeks to minimize gastrointestinal side effects and allow your body to adapt to the medication
Athletes perform best with 3-6mg/kg of caffeine [13]
So, what do we make of this obesity paradox. Evidence is building that the obesity paradox is a mirage caused by confounding in observational studies . The meta analysis for BMI-mortality association (Sources and severity of bias in estimates of the BMImortality association ) highlights three important biases that likely exist in survey-based estimates of BMI-mortality association: Residual confounding bias via within-BMI-group variation in body shape Positive survival bias in high-BMI samples due to recent weight gain (variation in duration of time with obesity) Negative survival bias in low-BMI samples via recent illness related weight loss Quick translation of the biases above: #1 says that there is some variation in body composition that is perfectly correlated with BMI (what we discussed above) #2 says that there are circumstances where someone has a lower BMI and is healthy but gains weight quickly just before the point of measurement and has not been at a high BMI for a long enough period of time to experience the negative effects of excess weight (pushing the average healthy BMI up)
As of our July 2026 check, program materials list Alabama, Arkansas, California, Kentucky, Louisiana, Mississippi, North Carolina, North Dakota, and South Carolina as excludedresidents of those states will need a different provider
