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A critical safety concern with GLP-1 receptor agonists is the potential risk of thyroid C-cell tumours

I also observed a worsening of pre-existing POTS symptoms a condition that, in hypermobile Ehlers-Danlos Syndrome, is not incidental but mechanistically downstream: a recognized consequence of defective extracellular matrix that can produce peripheral venous laxity, impaired lower-extremity vasoconstriction, chronic hypovolemia, and the compensatory hyperadrenergic state that characterizes the neuropathic POTS phenotype

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Answer: Take one tablet first thing in the morning on an empty stomach with no more than 4 oz of water, then wait at least 30 minutes before eating, drinking (including coffee), or taking any other oral medicines