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La activacin del IGF-1R desencadena sealizacin aguas abajo a travs de las vas PI3K/Akt/mTOR y MAPK/ERK los reguladores maestros del crecimiento celular, la sntesis de protenas y la proliferacin

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The lipid metabolisms including increased de novo lipogenesis and attenuation of lipolysis in the adipose tissue largely coordinate with glucose homeostasis response to insulin stimulation

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