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Protect from light during storage and handling (for example, keep vials in original packaging or a light-blocking container) to reduce light-driven degradation risk

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The two most researched mutations are C677T and A1298C

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Phosphinic peptides often share structural similarities with the transition-state of peptide substrate upon hydrolysis ( Figure 11 The phosphinic group is, as compared to, e.g., thiols and hydroxamic acids more weakly binding to zinc ions in metalloproteases and a significantly improved selectivity could be achieved by systematic variations of the side chains at P1 and P2 positions of 43

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